The essence of cell and tissue therapy lies in the active replacement and stimulation of influences on functionally defective cells and tissues in separate organs and systems, stimulation of the reparative and metabolic processes, immunological correction and stimulation.

The basis of the preparation production developed by us , cryogenic preservation, and treatment technologies lies the notion of the necessity of vitality preservation by biological objects, i.e. their ability to function after the unfreezing and introduction which ensures effective clinical results. The vital biological materials whose activity mechanisms are based on the preservation of a cells full value after thawing and the presence of metabolically active materials of natural origin possessing a poly-pharmacological effect of specific and non-specific direction. Along with the introduction of living cells, capable of proliferation, special attention should be paid to the application of sub-cellular extracts of embryonic and feto-placental origin. Naturally, there is a substantial difference between biological effects after introduction of living and not living fetal cells, as with the introduction of initial biological material and cells grown in culture. One of the advantages of the use of cell and tissue biological preparations is that the patient receives a number of biologically active balanced compounds of natural origin which are capable of influencing different sides of an integral organism's metabolism and also the cells ability to perform replacing functions.

Recently, it has become more and more obvious a fact that pharmacological drugs that have been anticipated for the development of new biochemical technologies, seldom justified those hopes especially in the cases of long-term diseases and auto-immune conditions, of metabolism disorders and a number of other pathologies. Cells and tissues of embryonic and fetal origin and also of cord blood were historically used as stimulators back in ancient times, and in the beginning of our century for rejuvenation and treatment of endocrine and hemopoietic diseases. This method was known in medicine as the "Brown-Sequard method'' according to the last name of its developer. Basically these were tissues of animal origin or cadaver tissues and their fragments. Successes in their application was not as significant as what could be expected in accordance with its theoretical preconditions. That is why these methods remained more of a possession of medical history rather than having found an appropriate place within the treatment of different disease complexes.

The development of the biological sciences, the broadening of our knowledge within the field of cell biology and its functional properties, as well as the development of methods for long-term storage, allowed researchers and clinicians to move on to a new, higher level of evaluation of stem cell and tissue preparations' potential abilities for the therapy of many complicated diseases. It is considered proven that embryonic stem cells possess a higher plasticity, they are able to withstand differentiation depending on the microenvironment, and at the same time their proliferation tempo is significantly higher than that of mature cells. Large quantities of growth factors, such as a fibroblasts' growth factor, nerves' growth factor, the factors stimulating the growth of macrophage and erythroid colonies as well as anti-proliferative cytokines preventing hyper-stimulation are present in embryonic, placental and fetal tissues.

Upon introduction of these preparations made of embryonic and fetal tissues, cells and their associates practically do not cause the immune reaction of rejection as in the 1st trimester of development the proteins of the 2nd histocompatibility class are not expressed upon them. The peculiarity of an embryonic stem cells' metabolism, which consists of the use of the glycolytic pathway, ensures them a higher resistance to various harmful factors, which accompany the process of extraction and low-temperature preservation.

Long-term methods of storage have been used in medical practice for a long time. Among those commonly famous methods of storage there is lyophilization, treatment by alcohol or formalin solutions and some other. But the basic drawback of such methods of storage is dehydration of protein compounds which cause cells and tissues to completely lose their main biological features - ability to function after transfusion

Nowadays, low temperatures are the only way which allows for the storage of cells and tissues for long time intervals (running for years) in a viable condition. Storage in liquid nitrogen at the temperature of -196 °C is the basic method of the long-term storage of biological objects today. The development of personal modern technologies of cryogenic-preservation, corresponding to world standards as well as observing the demands of producing biological preparations, their testing, marking and storing in accordance with statements of the European Tissue Banks Association, allowed us to create the supplies of high-quality cryogenically-preserved embryonic stem cells, tissue preparations and extracts for clinical application. We have developed a system of examination and treatment of patients with minimum risk and maximum effect with the most diversified pathologies. Stem cell therapy with application of our biological preparations were especially impressive in showing the biological and functional abilities in rejuvenation and improvement of life quality which is impossible to achieve with any other pharmacological, medical and preventive means.

During the embryonic development period of an animal or a human being, organs, especially the liver, produce (except for the numerous enzymes) a number of factors of differentiation for the various cells and tissues, and also hormone-like substances which function as the regulators of growth and an embryo's development. All of these biologically active compounds exist only during the intrauterine period of development, while the prototypes of artificial nature are much worse in their physiological effects.

But the most important is the presence of the suspension of the stem parenchyma as well as hemopoietic cells which can engraft in the adult organism and perform all their functions including the hemopoietic function. Researchers mark that only 3-5% of embryonic hepatocytes injected into a liver damaged by cirrhosis can normalize its function.

We have developed the ways of isolation and cryo-preservation of hemopoietic cells received from human embryonic liver, and cord blood as well as from stem cells of peripheral blood received from patients suffering from hemoblastosis after stimulation with cytostatics.

The efficiency of stem cell therapy is ensured through the latest special methods of bacteriological and virological control which guarantee the highest quality of preparations. Every preparation prepared for use is supplied with its own certificate containing test results which certify the safety of this biological preparation. The patient's safety assurance totally corresponds with international Standards of activity of the European and American Tissue Banks Association. We have developed a system that is based on total confidentiality, provides production of biological preparations in accordance with the necessary requirements concerning the selection, preparation for storage, storage and distribution of preparations for use in various medical institutions.