NICHOLAS KIPSHIDZE, MD, PhD
PERSONAL INFORMATION
Office Address: Lenox Hill Hospital
130 East 77th Street
Black Hall – 9th Floor
New York, NY 10021
Telephone: (212) 434-6835
Fax (212) 434-2205
Birth date: October 12, 1952
Citizenship: U.S.A.
EDUCATION AND TRAINING:
1970 Degree: B.S. (Honors) High School Number 1, Tbilisi, Georgia
1975 Degree: M.D Tbilisi State Medical School, Tbilisi
1982 Degree: Ph.D Bakulev Institute of Cardiovascular Surgery,
Moscow, USSR
1989 Degree: Doctor of Medical Bakulev Institute of Cardiovascular Surgery,
Science Moscow, USSR
POSTDOCTURAL TRAINING:
of Cardiology and Radiology Cardiovascular Surgery, Moscow, USSR
1978-1982 Clinical and Research Fellow Bakulev Institute of
Cardiovascular Medicine Cardiovascular Surgery,
Moscow, USSR
LICENSURE AND CERTIFICATION:
Year Type of License or certification
1975 USSR #146570
1994 USA #WI VP 9502
2002 European Cardiology Diploma
Year Academic Title Institution
1982-1992 Senior Clinical and Research Scientist Bakulev Institute
Department of Invasive Cardiology Cardiovascular Surgery
Moscow, USSR
1991-1992 Director, Catheterization Laboratory Bakulev Institute
(Elected by physicians) Cardiovascular Surgery
Moscow, USSR
1993-1995 Project Researcher, Dept of Cardiology Medical College of
Wisconsin, Milwaukee, WI
1995-1999 Visiting Professor of Medicine and Surgery Medical College of
Wisconsin, Milwaukee, WI
1995-1999 Associate Attending Physician Froedtert Memorial Lutheran
Hospital, Milwaukee, WI
1997-1999 Assistant Professor of Medicine Medical College of
Department of Cardiology Wisconsin, Milwaukee, WI
1999-present Director, Experimental and Molecular Cardiovascular Research
Catheter Interventions Foundation, New York, NY
1999 – Present Director, Department of Gene Institute of Clinical and
Therapy for Cardiovascular Disease Experimental Therapy,
(Voluntary position) Tbilisi, Georgia
2002-2004 Director, Experimental physiology Lenox Hill Heart and
and pharmacology Vascular Institute.
New York, NY
2004- present Associate director, Clinical Research, Lenox Hill Hospital
Department of Interventional
Cardiology
2004-present Director, Preclinical Research Lenox Hill Hospital
Department of Interventional
Cardiology
OTHER PROFESSIONAL POSITIONS AND MAJOR VISITING APPOINTMENTS:
Year Position Title Institution
1995-1999 Distinguished Visiting Professor
of Medicine and Surgery Medical College of
Wisconsin, Milwaukee, WI
2001-present Visiting Attending Physician Lenox Hill Hospital
New York, NY
AWARDS AND HONORS:
Year Name of Award/Honor
1996, 1997,1999, 2002 Who’s Who in Science and Engineering,
3th and 4th Edition
2001-2002 Strathmore’s WHO’S WHO LIFE TIME MEMBER
2003-2004 Honored Member American Register of Outstanding
Professionals
PROFESSIONAL SOCIETY MEMBERSHIPS:
Fellow of American College of Cardiology
Fellow of European Society of Cardiology
Senior Fellow of Society of Cardiac Angiography and Interventions
Fellow of American College of Angiology
Member of American Heart Association
Fellow of International College of Angiology
Fellow of International Union of Angiology
Member of New York Academy of Science
Member of Washington Academy of Science
Member of American Chemical Society
Member of Georgian Academy of Science
Member, New York State Chapter, American College of Cardiology
Member, Council of Clinical Cardiology- American Heart Association
Honored Member of East German Society of Cardiology
Honored Member of Cuban Society of Cardiology
Honored Member of Ecuadorian Society of Lymphology
Honored Member of Latin American Society of Angiology
Honored Member of Greek Society of Angiology
INVITED LECTURES, CONFERENCES (partial listing)
Chairman of Third Pan-American Congress of 1988
Phlebology and Angiology
Quitto, Ecuador
Chairperson 1989
15th World Congress of Angiology
Rome, Italy
Co-chairman 1990
Lasers in Cardiovascular Disease
Moscow, Russia
Co-chairman 1991
7th European Congress of Cardiology
Rhodes, Greece
Member of International Scientific Board 1991
of 7th European Congress of Cardiology
Faculty of Course: Discoveries in Radiation 1995
for Restenosis.
Emory University School of Medicine,
Atlanta, GA
Faculty of the International Conference: 1996
The Stent Summit, 10 Years of Stenting.
London, UK
Faculty of Course: Discoveries in Radiation 1997
Cardiology Research Foundation
Washington D.C.
Co-Chairman 1997
Fifth World Congress on Heart Failure
Washington D.C.
Co-Chairman 1997
International conference of Cardiovascular
Medicine and Science
Washington D.C.
Faculty of Advances in Cardiovascular 1998
Radiation Therapy
Cardiology Research Foundation
Faculty of Advances in Cardiovascular Radiation Therapy 1999
Washington, D.C.
Faculty of Transcatheter Cardiovascular Therapeutics 1999
11th Annual Symposium
Co-Chairman - 13th Congress of the European Chapter 1999
Of the International Union of Angiology
Co-Chairman - Scientific Conference Stent Grafts 1998
An Interdisciplinary Workshop
FDA, Washington, DC
Co-Chairmen – Embolotherapy 2000
Scientific Conference
FDA, Washington, DC
Co- Chairmen – Angiogenesis 2001
From bench to Bedside
FDA, Washington, DC
Course Director TCT 2000-2002
INVITED LECTURES:
“Laser Angioplasty” 1987
Pan-American Congress of Cardiology
Havana, Cuba
“Atherosclerosis” 1988
Third Pan-American Congress of Angiology
Quitto, Ecuador
“New Technologies in Arterial Recanalization” 1990
11th World Congress of Cardiology
Manila, Philippines
“New Methods of Treatment of Coronary Artery Disease” 1993
Medicine Towards 2000
Managua, Nicaragua
“Intravascular Laser Therapy” 1997
Queen Mary Hospital, Hong Kong
“Gene Therapy” 1998
New Delhi, India
“The Role of Angiogenesis in the Treatment of 1999
Arterial Disease”
Rhodes, Greece
INVITED SPEAKER (partial listing):
World Congress of Cardiology, 1978
Tokyo, Japan
World Congress of Cardiology, 1982
Moscow, USSR
European Congress of Cardiology, 1984
Dusseldorf, Germany
World Congress of Cardiology, 1986
Washington, D.C.
World Congress of Angiology, 1986
Munchen, Germany
International Conference: 1986
10 years Balloon Dilatation in Cardiovascular Disease,
Santiago, Spain
Pan-American Congress of Angiology, 1987
Havana, Cuba
European Congress of Cardiology, 1988
Vienna, Austria
Pan-American Congress of Angiology, 1988
Quitto, Ecuador
International Symposium-Lasers in Cardiovascular Diseases 1988
Vienna, Austria
International Symposium of Atherosclerosis, 1988
Rome, Italy
European Congress of Cardiology, 1989
Nice, France
Laser and Stent Therapy 1989
International Congress II
Scottsdale, Arizona
Fifth Annual Meeting of European Association 1991
of Cardiothoracic Surgery
London, U.K.
Red Light and Restenosis Interventional Conference: 1996
Discoveries in Radiation and Restenosis.
Emory University School of Medicine
Atlanta, GA
Fibrin Sealing International Conference: 1996
The Stent Summit. 10 Years of Stenting
London, U.K.
Advances in Cardiovascular Radiation, 1996
Red Light and Restenosis Therapy.
Emory University, Atlanta, GA.
10 Years of Stenting, Fibrin Sealing 1996
Royal Brompton Hospital, London, UK
Advances in Interventional Cardiology, 1996
Red Light Therapy for Restenosis,
Experience with Coronary Stents.
Amarstar Medical College, Amarstar, India.
Clinical Experience with Endoluminal Red 1996
Laser light Therapy.
Global Therapeutics Board Meeting, Broomfield, CO.
Impact of Low-Power Red Laser light on Restenosis. 1996
University of Leuven, Belgium.
Low-Power Laser Therapy (Experimental Studies). 1996
Annual Meeting of American Society of
Laser Medicine and Surgery. Orlando, FL.
Photobiomodulation of Vascular Wall. 1996
ACC, Orlando, FL.
Photostimulation of Vascular Healing Following 1996
Balloon Angioplasty.
European Congress of Cardiology, Birmingham, UK.
Intravascular Red Laser Light 1996
Therapy (experimental and clinical studies),
Long-Term Results with Freedom Stents, 1997
Worldwide Experiences with Freedom Stents.
Advances in Stenting, Sao-Paulo, Brazil.
Advances in Cardiovascular Radiation Therapy (6 topics). 1997
Washington Hospital Center, DC.
First Clinic al Experience with Endoluminal Red 1997
Laser Therapy, Current Approaches to Coronary
Artery Disease.
Annual Meeting of Chinese Society of Cardiology.
Advances in Cardiovascular Radiation 1998
Washington Hospital Center, DC
Stent Grafts- FDA conference 1998
Therapeutic Angiogenesis Conference 1999
Medical College of Wisconsin
Milwaukee, WI
World Congress of Angiology, 1989
Rome, Italy
World Congress of Angiology, 1990
Manilla, Philippines
International Conference-Laser Stent Therapy, 1990
Scottsdale, Arizona
World Congress for Transformation of Skeletal Muscle, 1990
Palm Springs, California
Asian Congress of Cardiology, 1991
Singapore
European Congress of Angiology, 1991
Athens, Greece
European Congress of Vascular Surgery, 1991
Warsaw, Poland
Annual Meeting of American College of Cardiology, 1994
Atlanta, Georgia
World Congress of Angiology, 1994
New York, NY
Restenosis Summit VI, 1994
Cleveland Clinic Foundation, Cleveland, Ohio
World Congress of Cardiology, 1994
Berlin, Germany
American Heart Association Meeting, 1994
Dallas, Texas
Transcatheter Cardiovascular Therapeutics, 1995
Washington, D.C.
Annual Meeting of the American College of Cardiology, 1995
New Orleans
European Congress of Cardiology, 1995
Amsterdam, Holland
American Heart Association Meeting 1995
Anaheim, CA
Annual Meeting of American College of Cardiology 1996
Orlando, FL
Annual Meeting of the American Society 1996
For Laser Medicine and Surgery
Orlando, FL
Annual Meeting of American College of Cardiology 1997
American Heart Association Meeting 1997
European Congress of Cardiology 1997
Stockholm. Sweden
American College of Cardiology 1998
Annual Meeting
American Heart Association 1998
Annual Meeting
Dallas, TX
TCT 1998
Washington, DC
Annual Meeting of American Society of Laser Medicine 1999
And Surgery
Orlando, FL
World Congress of Coronary Artery Disease 1999
Washington, DC
Interventional Cardiology Conference 1999
Tel Aviv, Israel
TCT 2000
Washington, DC
Angiogenesis and direct Myocardial
Revascularization 2000
CRT
Washington DC 2001
TCT 2001
Washington, DC
Interventional Cardiology 2001
London, UK
Angiogenesis conference 2001
Washington DC
Local drug Delivery summit 2002
Geneva, Switzerland
CRT 2002
Washington DC
American College of Cardiology 2002
Atlanta, Georgia
Cardiostim
World Congess for angiogenesis and cell 2002
Transplantation
Nice, France
TCT 2002
Washington, DC
CRT
Washington DC 2003
29th Annual Meeting of the Society for 2003
Biomaterials
Reno, Nevada
TCT 2003
Washington, DC
Offices and Committee Assignments in Professional Societies:
NIH Study section for SBIR in Surgery, 1997-Present
Radiology, and Bioengineering
NIH Study section for R01 1999-present
Scientific consultant of Metro Hospital and Heart 1998-present
Institute, New Delhi, India
Co-Principal Investigator for Cardiovascular Research, 1997-present
Training and device evaluation alliance. FDA
Member of Credentialing Committee
Society for Cardiac Angiography and Interventions 2001-present
Special Advisor: Institutional Biosafety Committee, 2001-present
Lenox Hill Hospital (subject: I9nstitutional Approval
and Regulation of Gene Therapy Trials)
EDITORIAL BOARDS:
Year Name of Board
2001 – Present International Journal of Cardiovascular Medicine
and Science (Associate Editor)
2002-Present Cardiovascular Radiation and Medicine
(Senior Editor)
2002-Present Journal of Heart Failure (Editorial board)
2004-Present European Journal of General Medicine (Editorial
Board
Reviewer: Journal of the American College of Cardiology
Reviewer: Coronary artery disease
Reviewer; Journal of Invasive Cardiology
Reviewer: Journal of Interventional cardiology
Reviewer: Catheterization and Cardiovascular Interventions
Reviewer: Journal Cardiothoracic surgery
Reviewer: Journal of Endovascular Therapy
Reviewer: Gene Therapy
Reviewer: Future Medicine
Reviewer: Evidence-based Cardiovascular Medicine
MAJOR RESEARCH INTERESTS:
My major interests include cardiovascular research, patient care and education in the broad subspecialty of interventional medicine. I have been involved in all aspects of biomedical research including device prototyping, medical engineering, experimental physiology, molecular biology, pre-clinical animal studies, animal modeling, pharmacology, biomaterials, the development and management of clinical trials, and regulatory processes. In last 5 years I have worked in the field of angiogenesis, phototherapy, cell transplantation, wound healing, drug eluting stents, gene therapy, antisense and etc. My research has led to the pioneering of several techniques to treat cardiovascular disease. As a result of my research in the aforementioned areas, I have authored more then 200 manuscripts, more then 400 abstracts and more than a dozen U.S. and international patents.
CURRENT ADMINISTRATIVE RESPONSIBILITIES:
Director of Endoluminal Molecular and Catheter
Interventions at the Cardiovascular Research Foundation
Director Experimental physiology and pharmacology
At Lenox Hill Heart and Vascular Institute
Visiting attending physician at Lenox Hill Hospital
TEACHING EXPERIENCE: I have taught and supervised medical students, physician assistants, residents, fellows, and Ph.D’s for past 20 years
Courses taught to Physicians & Residents: Atherosclerosis, interventional
cardiology, general cardiology and gene therapy of cardiovascular disease
GRANT SUPPORT:
Principal Investigator
Agency: USCI
Title: Cold Laser Light Ablation of Atherosclerotic Plaque
Grant Period: 12/92 – 3/94
Total Direct Costs: $78,106
Grant Period: 5/94-2/95
Total Direct Costs: $76,000
Agency: Global Therapeutics
Title: Red Light and Restenosis
Grant Period: 10/95-10/96
Total Direct Costs: $150,000
Grant Period: 10/96-10/97
Total Direct Costs: $150,000
Grant Period: 10/98-10/99
Total Direct Costs: $50,000
Agency: Antivirals Inc.
Title: Antisense treatment of restenosis
: Grant Period: 7/99 – 7/01
Total Direct Costs: $100,000, $150,000, $65,000
Agency: A. Ward Foundation
Title: Angiogenesis
Grant Period: 7/98 - 5/99
Total Direct Costs: $19,200.00
Agency: A.Ward Foundation
Title: Intramuscular application of
VEGF and fibrin
Grant Period: 7/99 - 5/00
Total Direct Costs: $20,000.00
Agency: A. Ward Foundation
Title: Laser Angiogenesis
Grant Period: 7/99 - 5/00
Total Direct Costs: $20,000.00
Agency: Bolton Medical
Title: Drug coated stents
Grant Period: 1/2000- 1/2003
Total direct costs $190.000.00
Agency: AVI - BioPharma
Title: Vaccine for Koksaki virus
Grant Period: 7/02 - 7/03
Total Direct Costs: $20,000.00
Agency Atrium Medical
Title: Local intracoronary delivery of Sirolimus
Grant Period: 7/02 - 7/03
Total Direct Costs: $120.000.00
Agency: Light –Science Technologies
Title: PDT therapy for vulnerable plaque
Grant Period: 7/02 - 7/03
Total Direct Costs: $250.000.00
Agency: Medtronic
Title: In vitro evaluation of different antirestenotic drugs
Grant Period: 7/01 - 7/02
Total Direct Costs: $26.000.00
Agency: Zynergy
Title: Evaluation of acive stent coatings
Grant Period: 7/01 - 12/01
Total Direct Costs: $22.000.00
Agency: Medtronic
Title: In vitro evaluation of different antirestenotic drugs
Grant Period: 7/01 - 7/02
Total Direct Costs: $26.000.00
Co-Principal investigator
Agency: NIH
Title: Bovine Pericardium Tissue Cover stents
Grant Period: $100.000.00
Total direct costs: 12/99-5/00
Agency: USA ID CDRFR
Title: Epidemiology of HTN in Republic of Georgia
Grant Period: 10/1997-10/1998
Total Direct Costs: $46.000.00
Agency: Leon Hess Foundation
Title: Gene Therapy for restenosis
Grant Period: 10/00- 10/03
Total Direct Costs: $380.000.00
Agency: Baxter Healthcare
Title: Therapeutic angiogenesis in patients with critical limb
Ischemia
Grant Period: 10/01- 7/03
Total Direct Costs: $36.000.00
Agency NIH
Title: Biodegradable drug eluting matrix for prevention of
Hemodialysis AV graft failure
01/03-12/03
$170.000.00
Agency: NIH
Title: Therapeutic application of Microbubbles
Grand Period: 7/00 - 7/02
Total Direct Costs: $526.000.00
Agency: AVI-Biopharma
Title: Safety and efficacy of local a delivery of antisense in patients with de novo and in-stent restenosis (AVAIL)
Grant Period: 10/01- 1/03
Total Direct Costs: $780.000.00
Agency FDA
Title: Safety and Efficacy of Drug-Device Combinations
For Treatment of Vascular Disease: Route of
Administration and Pharmacokinetics of a Steroid,
Antibiotic and Antitumor Agent
Grant period 5/03-5/04
Total Direct Cost: $149.991.00
PATENTS:
Apparatus for Minimizing Restenosis (USA)
Method for Sealing Blood Vessel Puncture Sites (USA)
Coated Intraluminal Stents (USA)
Method for Minimizing Restenosis (USA)
Method and apparatus for synchronized therapeutic treatment of a life form (USA)
Apparatus and method for delivering compounds to a living organism (USA)
Tacrolimus coated vascular stent (US patent pending)
Sirolimus eluting covered endoluminal prosthesis (US patent pending)
Apparatus and method for minimizing complications of drug coated stent implantation (US patent pending)
Endothelial Seeding of Arterial Wall (US patent pending)
Ultrasound Angiogenesis (US patent pending)
Method and Apparatus for Increasing cGMP in humans (US patent pending)
Tapering radially expandable Surgical Stent (US patent pending)
Vascular wraps for prevention of AV access graft failure (US patent pending)
Device to Treat Arterial Obstructions, No. 1383537 (Russia)
Laser Catheter, No. 1432838 (Russia)
Experimental Model for Blood Circulation, No. 1438654 (Russia)
Device for Modification for Laser Fibers, No. 1283893 (Russia)
ABSTRACTS (more than 400 abstracts)
REVIEWS
with advanced coronary heart disease. Rush or hope? Ter Arkh. 1999; 71(9):33-8. Review.
diseases. Int Angiol. 1999 Sep;18(3):185-92. Review.
JOURNALS (selected manuscripts from last 5 years)
1. Kipshidze N, Kipiani K, Bereidze N, Roubin G. Therapeutic angiogenesis for patients with limb ischemia by utilization of fibrin meshwork: pilot randomized controlled study. International Angiology 2003 - 2004 (in press).
2. Kipshidze N, Leon MB, Tsapenko M, Falotico R, Kopia GA, Moses J. Update on Sirolimus-Eluting Stents. Current Pharmaceutical Design 2004 (in press).
3. Kipshidze NN, Iversen P, Kim HS, Yiazdi H, Dangas D, Seaborn R, New G, Tio F, Mehran R, Tsapenko M, Stone GW, Roubin GS, Iyer S, Leon MB, Moses JW. An advanced c-myc Antisense AVI-4126) Eluting Phosphorylcholine-coated (PC) stent implantation is Associated with Complete Vascular Healing and Reduced Neointimal Formation in the Porcine Coronary Restenosis Model. Catheterization and Cardiovascular Interventions 2003-2004 (in press).
4. Chekanov V, Kipshidze N. Angiogenesis by means of endothelial cell transplantation. J Thorac Cardiovasc Surg. 2003 Feb; 125(2):441-2.
5. Kipshidze N, Iversen P, Keane E, Stein D, Chawla P, Skrinska V, Shankar LR, Mehran R, Chekanov V, Dangas G, Komorowski R, Haudenschild C, Khanna A, Leon M, Keelan MH, Moses J. Complete vascular healing and sustained suppression of neointimal thickening after local delivery of advanced c-myc antisense at six months follow-up in a rabbit balloon injury model. Cardiovasc Radiat Med. 2002 Jan-Mar;3(1): 26-30.
6. Chekanov VS, Nikolaychik V, Maternowski MA, Mehran R, Leon MB, Adamian M, Moses J, Dangas G, Kipshidze N, Akhtar M. Deferoxamine enhances neovascularization and recovery of ischemic skeletal muscle in an experimental sheep model. Ann Thorac Surg. 2003 Jan; 75(1): 184-9.
7. El-Omar MM, Dangas G, Mehran R, Lansky AJ, Kipshidze NN, Polena S, Fahy M, Moussa I, Glasser L, Moses JW, Stone GW. Leon MB. Usefulness of atrial fibrillation as a marker of outcome after percutaneous coronary intervention. Am J Cardiol. 2003 Jan 15; 91(2):232-4.
8. Chekanov V, Akhtar M, Tchekanov G, Dangas G, Shehzad MZ, Tio F, Adamian M, Colombo A, Roubin G, Leon MB, Moses JW, Kipshidze NN. Transplantation of autologous endothelial cells induces angiogenesis. Pacing Clin Electrophysiol. 2003 Jan;26 (1 Pt 2): 496-9.
9. Chekanov VS, Rayel R, Nikolaychik V, Kipshidze N, Baibekov I, Karakozov P, Bajwa T, Akhtar M. Direct fibrin injection to promote new collateral growth in hind limb ischemia in a rabbit model. J Card Surg. 2002 Nov-Dec; 17(6):502-12.
10. Kipshidze N, Moussa I, Nikolaychik V, Chekanov V, Khanna A, Colombo A, Leon MB, Moses J. Influence of Class I interferons on performance of vascular cells on stent material in vitro. Cardiovasc Radiat Med. 2002 Apr-Jun;3(2):82-90.
11. New G, Moses JW, Roubin GS, Leon MB, Colombo A, Iyer SS, Tio FO, Mehran R, Kipshidze N. Estrogen-eluting phosphorylcholine-coated stent implantation is associated with reduced neointimal formation but no delay in vascular repair in a porcine coronary model. Catheter Cardiovasc Interv. 2002 Oct; 57(2):266-71.
12. Moses JW, Kipshidze N, Leon MB. Perspectives of Drug-Eluting Stents – The next revolution. Am J Cardiovasc Drugs 2002: 2 (3).
13. Johnson WD, Moses J, Kipshidze N. Absence of Chlamydia pneumoniae in surgical specimens of coronary and carotid arteries by polymerase chain reaction. Cardiovascular Radiation Medicine 2002: 2: 1-4.
14. Kipshidze NN, Kim HS, Iversen P, Yazdi HA, Bhargava B, New G, Mehran R, Tio F, Huadenschild C, Dangas G, Stone GW, Iyer S, Roubin GS, Leon MB, Moses JW. Intramural coronary delivery of advanced antisense oligonucleotides reduces neointimal formation in the porcine stent restenosis model. J Am Coll Cardiol. 2002 May 15;39(10): 1686-1691
15. DeScheerder IK, Wang K, Kaul U, Singh B, Sahota H, Keelan MH, Kipshidze NN, Moses J. Intravascular low-power laser irradiation after coronary stenting: long-term follow-up. Lasers Surg Med. 2001; 28(3):212-5.
16. Kipshidze N, Nikolaychik V, Keelan MH, Shankar LR, Khanna A, Kornowski R, Leon M, Moses J. Low-power helium: neon laser irradiation enhances production of vascular endothelial growth factor and promotes growth of endothelial cells in vitro. Lasers Surg Med. 2001; 28(4):355-64.
17. Kipshidze N, Moses JW, Leon MB. Paclitaxel-coated stent: is there a light at the end of the tunnel? J Am Coll Cardiol. 2001 Jul; 38(1):292-3. No abstract available.
18. Kipshidze N, Sahota H. Photoangioplasty recount: clear punch or dimpled chad? Circulation. 2001 Sept 11; 104(11):E55-6. No abstract available.
19. Kipshidze N, Keane E, Stein D, Chawla P, Skrinska V, Shankar LR, Khanna A, Komorowski R, Haudenschild C, Iversen P, Leon MP, Keelan MH, Moses J. Local delivery of c-myc neutrally charged antisense oligonucleotides with transport catheter inhibits myointimal hyperplasia and positively affects vascular remodeling in the rabbit balloon injury model. Catheter Cardiovasc Interv. 2001 Oct; 54(2):247-56.
20. Kipshidze N, Nikolaychik V, Muckerheidi M, Keelan MH, Chekanov V, Maternowski M, Chawla P, Hernandez I, Iyer S, Dangas G, Sahota H, Leon MB, Roubin G, Moses JW. Effect of short pulsed nonablative infrared laser irradiation on vascular cells in vitro and neointimal hyperplasia in a rabbit balloon injury model. Circulation. 2001 Oct 9; 104(15):1850-5.
21. Johnson WD, Chekanov VS, Nikolaychik VV, Kipshidze N. Vineberg procedure combined with therapeutic angiogenesis: old wine in a new bottle. Ann Thorac Surg. 2001 Oct; 72(4): 1443-4. No abstract available.
22. DeScheerder IK, Wang K, Zhou Xr, Szilard M, Verbeken E, Ping QB, Yanming H, Jianhua H, Nikolaychik V, Moses JW, Kipshidze N, Van de Werf F. Optimal dosing of intravascular low-power red laser light as an adjunct to coronary stent implantation: insights from a porcine coronary stent model. J Clin Laser Med Surg. 2001 Oct: 19(5):261-5.
23. Kipshidze N, Petersen JR, Vossoughi J, Nikolaychik V, Bakhutashvili I, Roubin GS, Leon MB, Moses JW. Low-power laser irradiation increases cyclic GMP synthesis in penile smooth muscle cells in vitro. J Clin Laser Med. Surg. 2000 Dec; 18(6):291-4.
24. Kipshidze N, Chekanov V, Chawla P, Shankar LR, Gosset JB, Kumar K, Hammen D, Gordon J, Keelan MH. Angiogenesis in a patient with ischemic limb induced by intramuscular injection of vascular endothelial growth factor and fibrin platform. Tex Heart Inst J. 2000; 27 (2):196-200.
25. Kipshidze N, Ferguson JJ 3rd, Keelan MH Jr, Sahota H, Komorowski R, Shankar LR, Chawla PS, Haudenschild CC, Nikolaychik V, Moses JW. Endoluminal reconstruction of the arterial wall with endothelial cell/glue matrix reduces restenosis in an atherosclerotic rabbit. J Am Coll Cardiol. 2000 Oct; 36(4):1396-403.
26. Kipshidze N, Keelan MH, Petersen JR, Bachutashvili I, Vossoughi J, Karanian J, Ghosh C, Iversen P, Roubin GS, Leon MB, Moses JW. Photoactivation of vascular iNOS and elevation of cGMP in vivo: possible mechanism for photovasorelaxation and inhibition of restenosis in an atherosclerotic rabbit model. Photochem Photobiol. 2000 Oct; 72(4):579-82.
27. DeScheerder I, Wang K, Nikolaychik V, Kaul U, Singh B, Sahota H, Keelan MH, Kipshidze N. Long-term follow-up after coronary stenting and intravascular red laser therapy. Am J Cardiol. 2000 Nov 1; 86(9):927-30.
28. Nikolaychik V, Kipshidze N. Liquid glue for vascular sealing: is Duett’s composition safe and effective? Catheter Cardiovasc Inter. 2000 Nov; 51(3):371-2. No abstract available.
29. Nikolaychik VV, Sahota H, Keelan MH Jr. Chawla PS, Hernandes II, Ferguson JJ, 3rd, Kipshidze N. Influence of Different Stent Materials on endothelialization In Vitro. J Invasive Cardiol. 1999 July; 11(7):410-415.
30. Khanna A, Shankar LR, Keelan MH, Kornowski R, Leon M, Moses J, Kipshidze N. Augumentation of the expression of proangiogenic genes in cardiomyocytes with low dose laser irradiation in vitro. Cardiovasc Radiat Med. 1999 Jul-Sep; 1(3):265-9.
31. Kipshidze, N., Chekanov, V., Kappes, S., Abdurahman, A., Hammen, D.,
Chawla, P., Nikolaychik, V., Haudenschild, C., Keelan, M.H.,
Therapeutic Angiogenesis for Critical Limb Ischemia to Limit or Avoid
Amputation. Journal of Invasive Cardiology, Vol. 11, No. 1, January 1999, 25–
32. Grim CE, Grim CM, Petersen JR, Li J, Tavill F, Kipshidze NN, Chawla PS, Kipshidze N. Prevalence of cardiovascular risk factors in the Republic of Georgia. J Hum Hypertens. 1999 Apr; 13(4):243-7.
33. Kipshidze N, Chawla P, Keelan MH. Fibrin meshwork as a carrier for delivery of angiogenic growth factors in patients with ischemic limb. Mayo Clin Proc. 1999 Aug; 74(8): 847-8.
34. Kipshidze N, Vascular endothelial growth factor: promise or peril? Am J Cardiol. 1999 Jun 1; 83(11): 1592. No abstract available.
35. Karsanov NV, Sukoian GV, Karsanov VN, Tatulashvili DR, Kipshidze NN. The action of a number of cardiac glycosides on an isolated system of myocardial contractile proteins in heart failure due to toxic-allergic myocarditis. The molecular mechanism. Eksp Klin Farmakol. 1999 July-Aug; 62(4):18-25. Russian.
36. Sahota H, Kipshidze N. Perfusion balloon – come back kid or forgotten past. Am J Cardiol. 1999 Nov 15; 84(10):1279-80. No abstract available.
37. Kipshidze N, Chekanov VV, Kappes S, Abdurahman A, Hammen D, Chawla PS, Nikolaychik VV, Haudenschild C, Keelan MH Jr. Therapeutic Angiogenesis for Critical Limb Ischemia to Limit or Avoid Amputation. J Invasive Cardiol. 1999 Jan; 11(1):25-28. No abstract available.
38. Kipshidze N, Johnson WD, Haudenschild CC. Therapeutic Angiogenesis in Patients with Advanced Coronary Artery Disease: Hype or Hope? J Invasive Cardiol 1999 Oct; 11(10):589-599. No abstract available.
39. Grim, C.E., Grim, C.M., Petersen, JR, Li, J., Tavill, F., Kipshidze, N.,
Chawla, P. Prevalence of Cardiovascular Risk Factors in the Republic
of Georgia. Journal of Human Hypertension, 1999, 13:243-247.
40. Kipshidze, N., Keelan, M., Efficacy of Coronary Interventions at the End of
the Millenium: Is There Light at the End of the Tunnel. Journal of the
American College of Cardiology, March 1999, 19:9.
41. Kipshidze, N., Keelan, M.H., Horn, J., Chawla, P., Nikolaychik, V., Biomodulation of Vascular Cells with Low-Power Red Laser Light in Vitro. International Journal of Cardiovascular Medicine and Science, Vol. I, No. 3 & 4, pp. 241-245, 1998.
42. Sahota, H., Kipshidze, N., Chawla, P., Autoperfusion Balloon Angioplasty Past, Present and Future. International Journal of Cardiovascular Medicine and Science, Vol. I, No. 3 & 4, pp. 221-226, 1998.
43. Kaul, U., Singh, B., Sudan, D., Ghose, T., Kipshidze, N., Intravascular Red Light Therapy after Coronary Stenting - Angiographic and Clinical Follow-up Study In Humans. Journal of Invasive Cardiology, 1998; 10:534-538.
44. Kipshidze N, Ferguson JJ 3rd, Macris MP, Clubb F, Cloy M, Horn J, Sperl F, Sahota H, Keelan MH Jr, Nikolaychik VV. Percutaneous Application of Fibrin Sealant to Achieve Hemostasis Following Arterial Catheterization. J Invasive Cardiol. 1998 Apr; 10(3):133-141.
45. DeScheerder IK, Wang K, Zhou XR, Verbeken E, Keelan MH Jr., Horn JB, Sahota H, Kipshidze N. Intravascular Low Power Red Laser Light as an Adjunct to Coronary Stent Implantation Evaluated in a Porcine Coronary Model. J Invasive Cardiol. 1998 June; 10(5):263-268.
46. Kaul U, Singh B, Sudan D, Ghose T, Kipshidze N. Intravascular Red Light Therapy after Coronary Stenting N Angiographic and Clinical Follow-up Study in Humans. J Invasive Cardiol. 1998 Nov; 10(9):534-538.
47. Nikolaychik, V.V., Ferguson, J.J., Lelkes, P.I., Horn, J., Kipshidze, N. Fibrin meshwork sealing after artery catheterization: optimization and mechanisms. International Journal of Cardiovascular Medicine and science, Vol !, No 2, pp 191-198, 1998
48. Kipshidze N, Sahota H, Komorowski R, Nikolaychik V, Keelan MH Jr. Photoremodeling of arterial wall reduces restenosis after balloon angioplasty in an atherosclerotic rabbit model. J Am Coll Cardiol 1998 Apr; 31(5): 1152-7.
49. Nikolaychik, V.V., Kipshidze, N.N. Optimization of fibrin-sealant composition for securing of entry sites following artery catheterization. Global Therapeutics, Inc., Broomfield, CO, USA
50. Kipshidze, N., Ferguson III, J.J., Marcris, M.P., Clubb, F., Cloy, M., Horn, J.,
Sperl, F, Sahota, H., Keelan, M.H., Nikolaychik, V. Percutaneous Application
of Fibrin Sealant to Achieve Hemostasis Following Atrial Catheterization. J Invas Cardiol 1998; 10:133-141.
51. De Scheerder, I.K., Wang, K., Zhou, X., Sahota, H., Kipshidze, N. Intravascular low power red laser light as an adjunct to coronary stent implantation evaluated in a porcine coronary model. J Invasive Cardio 1998; 10:263-268.