Lixian Jiang
U.S Patent and Trademark Office
License number: 57787
China Bar Association
Certificate number: 019973021195
License number: 181499120084.
University of South Florida, Florida/ USA
PhD 8.2000 - 8.2006
Medical Science
Academy of Military Medical Science, Beijing/ China
M.S. 8.1994 - 8.1997
Medical Science
China University of Political Science and Law, Beijing/ China
Law Training Program. 8.1997 - 8.1999
Law
Hunan Normal University, Department of Biology, Hunan/ China
B.S. 8.1990 - 8.1994
Biology
Cedar Patent LLC, Tampa/ Florida, USA
Patent Prosecution Agent 12.2003- 6.2006
• Performed inventor interviews.
• Drafted computer science patent applications in the area of msql database and Macromedia flash communication server software.
• Performed prior art searches for medical science and chemistry patents.
• Drafted and prosecuted medical science patent applications in the fields of Chinese medicine, western blotting, PCR, immunohistochemistry staining, cell cryo-preservation, gene transfer, including a patent for PEP nadir and its apparatus.
• Drafted more than 5 mechanical patent applications, including, e.g. “convenient bowling bag” and “easy assembled and transported cases and bags with wheels”.
• Prosecuted Trademark applications
• Docketed patent/ trademark files; maintained docket of all due dates for patent and trademark cases
Sounding Intellectual Property Counsel Sino Co. Ltd. Shanghai/China
Patent and Trademark Attorney 12.2002 - 8.2003
• Performed inventor interviews.
• Performed patent prior art searches in the area of medical science and chemistry.
• Drafted and prosecuted patent applications in the areas of mechanic, chemistry, medical sciences, including, e.g. effective component refinement from Chinese herb, drug delivery, specific high protein expression with gene transfer, convenient comb of western blotting, improved background wash for immunohistochemistry staining.
• Prosecuted trademark applications, including Publix and Pluglink.
• Performed intellectual property litigation in petition, infringement and disputation.
• Docketed patent/ trademark files; maintained docket of all due dates for patent and trademark cases.
B.J.H. Law Firm Beijing/ China
Assistant Patent Attorney 8.1999-8.2000
• Interviewed inventors and provided counseling services in patent and trademark application
• Performed prior art research for medical science and chemistry patents.
• Analyzed, summarized, organized and compiled documents and information regarding intellectual property laws and regulations for the Chief Attorney.
• Docketed patent/ trademark files; maintained docket of all due dates for patent and trademark cases
Neurosurgery Dept, University of South Florida, Tampa/Florida
PhD Research Assistant 8. 2000 - 8.2006
• Performed stem cells isolation from human umbilical cord blood, performed stem cell cryo-preservation, and transplantation in stroke animals.
• Performed stem cell culture, and other molecular biology assay.
Trauma Center, 304th Hospital, Beijing/ China
Postdoctoral Fellow 8.1997 - 8.1999
• Performed oncogene assay and growth factor expression examination in sever burned patients.
Academy of Military Medical Science, Beijing/ China
M.S. research Assistant 8.1994 -8.1997
• Studied neuron apoptosis (Programmed Cell Death) in rat brain following acute hypoxia
PUBLICATIONS:
1. Lixian Jiang; Steve Poulos, Tanja Zigova, P. R. Sanberg, Keith R. Pnnypaker and A. E. Willing. Changes in cellular proliferation in the brain of Sprague-Dawley rats after stroke. Experimental Neurology, 175:439,2002
2. Lixian Jiang, A.E. Willing, M. Milliken, S. Poulos, J. Sanchez-Ramos, T. Zigova, S. Song, J. Chen, M. Chopp, and P. R. Sanberg. Intravenous or intracranial transplantation of umbilical cord mononuclear cells reduces hyperactivity in a rodent model of stroke. Experimental Neurology, 170:198,2001
3. Lixian Jiang, Mary Newman, Sameul Saporta, Ning Chen, Cyndy Davis Sanberg, Paul R. Sanberg, Alison E. Willing In vitro evidence for MIP-1α and MCP-1β Regulation Systemically Delivered human umbilical cord blood migration into brain after stroke in rats. Stroke (in press)
4. Lixian Jiang, Mary Newman, Sameul Saporta, Ning Chen, Cyndy Davis Sanberg, Paul R. Sanberg, Alison E. Willing. Human umbilical cord blood depress microglia inflammatory response in vitro. Journal of Neuroscience (In press)
5. Willing
AE, Lixian J, Milliken M, Poulos S, Zigova T, Song S, Hart C,
Sanchez-Ramos J, Sanberg PR. Intravenous versus intrastriatal cord blood
administration in a rodent model of stroke.
J Neurosci Res. 2003 Aug 1; 73(3): 296-307.
6. ALISON E. WILLING, LIXIAN JIANG, PAUL NOWICKI, STEVE POULOS, MELISSA MILLIKEN, DAVID W. CAHILL, PAUL R. SANBERG. EFFECTS OF MIDDLE CEREBRAL ARTERY OCCLUSION ON SPONTANEOUS ACTIVITY AND COGNITIVE FUNCTION IN RATS International Journal of Neuroscience Volume 112, Number 5 / May 2002 Pages: 503 – 516
7. AE Wiling, S Saporta, Lixian Jiang, Melissa Milliken, Steve Poulos, Scott S Bowersox and P.R. Sanberg. Preliminary of the behavior effect of LBS-Neuron Implantation on seizure susceptibility following middle cerebral artery occlusion in the rat. Neurotoxicity Research, 2002:111-118, 4(2).
8. Ning Chen, Jennifer E. Hudson, Piotr Walczak, Iwona Misiuta, Svitlana Garbuzova-Davis, Lixian Jiang, Juan Sanchez-Ramos, Paul R. Sanberg, Tanja Zigova, Alison E. Willing. Human Umbilical Cord Blood Progenitors: The potential of these hematopoietic cells to become neural. Stem Cells Oct 2005; 23: 1560 - 1570 ; doi:10.1634/stemcells.2004-0284
9. JIANG Lixian, FU Xiaobing, SUN Tongzhu, YANG Yinhui, GU Xiaoman. Relationship between oncogene c-jun activation and fibroblast growth factor receptor expression of ischemia-reperfusion intestine in rats. Shjie Huaren Xiaohua Zazhi 1999, 7(6):498-500.
10. Lixian Jiang，Xiaobing FU Application of gene therapeutic technology in tissue repair. Chinese Journal of Plastic Surgery and Burns, 1999(3): 228-230 (review).
11. JIANG Lixian, FU Xiaobing, SUN Tongzhu, YANG Yinhui, GU Xiaoman. Expression of onco-gene c-fos and c-jun in kidney after intestinal ischemia- reperfusion. Chinese Critical Care Medicine, 1999; 11(12): 728-730.
12. JIANG Lixian, FU Xiaobing, SUN Tongzhu, Wang Yaping, YANG Yinhui. Programmed cell death in skeletal muscle after limb ischemia-reperfusion injury. Chinese Critical Care Medicine, 1998;10(8):473-475.
13. Lixian Jiang，Xiaobing FU Programmed cell death during tissue injury repair and regeneration. Chinese Journal of Reparative and Reconstructive Surgery, 1998; 12(6): 376-379(review).
14. Lixian Jiang, Xie Yinzhi, Sun Xingbin, Yin Zhaoyun. Relationship between apoptosis of brain cells and free radical scavenging ability in rats during acute intermittent hypoxia. Space Medicine & Medical Engineering, 1998; 11(2):83-86.
15. JIANG Lixian, Xie Yinzhi，Sun Xingbin, Yin Zhaoyun. The evidence of programmed cell death in rats brain during acute intermittent hypoxia. Chinese Journal of Applied Physiology, 1998;14(1):10-13.
16. JIANG Lixian, Xie Yinzhi，Sun Xingbin, Yin Zhaoyun，LV Yongda The Changes of free radical scavenge system in acute hypoxia rat brain. Chin J Appl Physiol 1997:13(3)Suppl.
17. GU Xiaoman, FU Xiaobing, YANG Yinhui, SUN Tongzhu and JIANG Lixian Expression characteristics of c-fos, c-myc and bFGF in early burn tissue Chin Med J 2001;114( 9):925-928.
18. FU Xiaobing, JIANG Lixian, SUN Tongzhu, YANG Yinhui, GU Xiaoman and SHENG Zhiyong Expression of oncoproteins c-fos and c-jun in hypertrophic scars and chronic dermal ulcers and their regulation of basic fibroblast growth factor. Chin Med J 2001;114(8):852-856
19. GU Xiaoman, FU Xiaobing, YANG Yinhui, SUN Tongzhu and JIANG Lixian mRNA and Protein expression of transcription factor c-fos in burned rats and their effects on wound healing. Chinese Journal of Traumatology. 2000;3(3):141-145
20. GU Xiaoman, FU Xiaobing, YANG Yinhui, SUN Tongzhu and JIANG Lixian Relationship between basic fibroblast growth factor and protor oncogenes in process of wound healing. Chin J Traumatol, June 2000,vol 16 340-343
21. GU Xiaoman, FU Xiaobing, YANG Yinhui, SUN Tongzhu and JIANG Lixian The expression of transcription factor c-fos mRNA and its protein in the burn wound of rats. Chin J Burns, June 2000 vol 16: 180-182
22. FU Xiaobing, JIANG Lixian, SUN Tongzhu, YANG Yinhui, GU Xiaoman, SHENG Zhiyong. The significance and characteristics of the gene expression of c-fos and c-jun in hypertrophic scar and chronic ulcer tissues. Chin J Burns, June 2000 vol 16(5): 300-302.
23. FU Xiaobing, YANG Yinhui, SUN Tongzhu, JIANG Lixian, GU Xiaoman, SHENG Zhiyong. The effect of acute ischemia-reperfusion on expression of endogenous bFGF and its receptor. Chin J Surg, Jan 2000, 38(1):77 .
24. Sun Xiaoqing, FU Xiaobing, YANG Yinhui, SUN Tongzhu, JIANG Lixian, GU Xiaoman, SHENG Zhiyong. The effect of basic fibroblast growth factor on the injuries of liver and intestine induced by ischemia-reperfusion in rats. Chinese Critical Care Medicine, August 2000 12(8): 460-462.
25. FU Xiaobing, SUN Tongzhu, YANG Yinhui, JIANG Lixian, GU Xiaoman, SHENG Zhiyong. Characteristics of bFGF and TGF-ß expression in dermal chronic ulcers and hypertrophic scars and their effects on tissue repair. Chinese J Reparative and Reconstructive Surgery 2000, 14(5):271-274.
26. FU Xiaobing, JIANG Lixian, YANG Yinhui, SUN Tongzhu, GU Xiaoman, SHENG Zhiyong. Expression of c-fos and c-jun in injury lung and their effect on bFGF. Med J Chin PLA , 2000, 25(6):432-434.
27. FU Xiaobing, YANG Yinhui, SUN Tongzhu, JIANG Lixian, GU Xiaoman, CHANG Guoyou, SHENG Zhiyong. Study on expression of bFGF and TGF-ß regulated by activated protooncogenes in lung and their effects for lung repair after ischemia and reperfusion insult. J Trauma Surg 2000, 2(2):89-92.
28. YANG Yinhui, FU Xiaobing, SUN Tongzhu, JIANG Lixian, GU Xiaoman. The effect of exogenous basic fibroblast growth factor on hepatic endogenous basic fibroblast growth factor and fibroblast growth factor receptor expression after intestinal ischemia-reperfusion injury. Chinese Critical Care Medicine, 1999; 11(12): 734-736.
29. YANG Yinhui, FU Xiaobing, SUN Tongzhu, JIANG Lixian, GU Xiaoman. The effect of bFGF on the expression of intestine exogenous basic fibroblast growth factor and TGF-ß after ischemia reperfusion insult. Shjie Huaren Xiaohua Zazhi 1999; 7(9):793-794.
30. YANG Yinhui, FU Xiaobing, SUN Tongzhu, JIANG Lixian, GU Xiaoman. Renal endogenous expression of basic fibroblast growth factor and transforming growth factor ß after intestine ischemia-reperfusion injury. Chinese Critical Care Medicine. 1999; 11(4):203-205.
31. GU Xiaoman, FU Xiaobing, YANG Yinhui, SUN Tongzhu, JIANG Lixian. The expression characteristics of c-fos, c-myc and bFGF in early burned tissues. Med J NDFNC 1999 Dec; 20(4):254-256.
32. Fu Xiaobing, Jiang Lixian, Sun Tongzhu, Yang Yinhui, Chang Guoyou, Li Quanyue，Sheng Zhiyong The relationship between three kind of ulcers and apoptosis. Med J. Chin PLA 1999; 24(5):361-367.
33. Fu Xiaobing, Yang Yinhui, Sun Tongzhu, Wang Yaping, Jiang Lixian, Sheng Zhiyong. The gene expression of basic fibroblast growth factor and transforming growth factor ß in rat kidneys after gut ischemia and reperfusion. Chinese Journal of Pathophysiology. 1999; 15(11):1034-1037.
34. YANG Yinhui, FU Xiaobing, Li Quanyue，SUN Tongzhu, JIANG Lixian, GU Xiaoman. The characteristics of bcl-2 expression in hypertrophic scars and ulcers and its implication. Chin J Exp Surg, July 1999; 16(4):302-303
35. Fu Xiaobing, Yang Yinhui, Jiang Lixian, Sun Tongzhu, Wang Yaping, Sheng Zhiyong. Different expression of bFGF gene in three kinds of skeletal muscles. Natl Med J Chin, Sep 1999; 79(9):702-704.
36. Fu Xiaobing, Sun Tongzhu, Wang Yaping,Yang Yinhui, Jiang Lixian, GU Xiaoman, Chang Guoyou, Sheng Zhiyong. Comparative study of epidermal growth factor and basic fibroblast growth factor on wound healing. Chinese J Reparative and Reconstructive Surhery, 1999; 13(5): 278-282.
37. Fu Xiaobing，Yang Yinhui, Sun Tongzhu, Jiang Lixian, Gu xiaoman, Chang Guoyou, Sheng Zhiyong Changes in endogenous basic fibroblast growth factor and transforming growth factor ß in lung induced by intestinal ischemia-reperfusion injury. Chinese Critical Care Medicine, 1999;11(6):332-334
38. Fu Xiaobing，Yang Yinhui, Sun Tongzhu, Jiang Lixian, Sheng Zhiyong. Bcl-2 gene expression and its effect on apoptosis in intestine after ischemia-reperfusion in rats. Chinese Critical Care Medicine, 1999;11(8):459-461.
39. YANG Yinhui, FU Xiaobing, SUN Tongzhu, JIANG Lixian. bFGF and TGFß mRNA expression in liver and lungs following intestinal ischemia reperfusion injury in rats. Shjie Huaren Xiaohua Zazhi 1998, 6(10):850-852.
40. Fu Xiaobing, Jiang Lixian, Yang Yinhui, Sun Tongzhu, Wang Yaping, Zhou Baotong, Sheng Zhiyong. Induction of gut mucosa necrosis and apoptosis after ischemia-reperfusion and the effects of fibroblast growth factor. Chinese Critical Care Medicine, 1998;10(8):455-458.
41. Fu Xiaobing, Yang Yinhui, Sun Tongzhu, Jiang Lixian, Wang Yaping, Zhou Baotong, Sheng Zhiyong. Basic fibroblast growth factor and transforming growth factor ß gene expression in intestine after ischemia-reperfusion in rats. Chinese Critical Care Medicine, 1998;10(8):459-462
42. YANG Yinhui, FU Xiaobing, SUN Tongzhu, JIANG Lixian, Wang Yaping, Zhou Baotong. Transforming growth factor ß and basic fibroblast growth factor gene expression in liver following intestinal ischemia reperfusion injury in rats. Chinese Critical Care Medicine, 1998;10(8):463-466.
43. YANG Yinhui, FU Xiaobing, SUN Tongzhu, Wang Yaping, JIANG Lixian, Sheng Zhiyong. The expression of Transforming growth factor ß in skeletal muscle after limb ischemia-reperfusion injury. Chinese Critical Care Medicine, 1998;10(11):677-678.
44. YANG Yinhui, FU Xiaobing, SUN Tongzhu, JIANG Lixian, Wang Yaping, Zhou Baotong, Sheng Zhiyong. Intestinal reperfusion up-regulates endogenous bFGF and TGFß gene expression in the lung. Med J Chin PLA 1998; 23(5): 407-409.
45. Fu Xiaobing, Yang Yinhui, Wang Yaping, Sun Tongzhu, Jiang Lixian, Sheng Zhiyong. Ischemia and reperfusion reduce the mRNA expression of endogenous basic fibroblast growth factor (bFGF) in rat skeletal muscles. Natl Med J China, 1998; 78(9):696-698.
46. Jiang L, Willing AE, Hushen J, Cameron DF, Zigova T, Song S, Sanchez-Ramous, Freeman TB, Sanberg PR. The effect of rat sertoli cell conditioned medium on survival of umbilical cord blood cells. Program No. 138.13, 2001 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2001. CD-ROM.
47. Lixian Jiang, C.J. Cassady, J.Mallery, T. Zigova, J. Sanchez-Ramous, S. Song, P.R.Sanberg, A.E. Willing. Does Administration of umbilical cord blood stem cells alter the inflammatory response after stroke? Program No. 389.4 2002 Abstracts Viewer/Itinerary Planner. Washington DC; Society for Neuroscience, 2002. CD-ROM.
48. S Saportal, Lixian Jiang, A. E. Willing, S. Poulos, S.S. Bowersox, and P. R. Sanberg. Behavioral effects of LBS-Neurons implantation on seizure susceptibility in rats with focal ischemic brain injuries. ASNTR 2001. (Experimental Neurology).
49. Jiang L, Newman M, Sapota S, Davis C, Sanberg PR, Willing AE. Do chemokines from ischemic brain induce migration of human umbilical cord blood cells? Health Science Center Research Day. Feb. 2004.
50. Yang Yinhui, Fu Xiaobing, Sun Tongzhu, Jiang Lixian, Wang Yaping，Zhou Baotong，Sheng Zhiyong The effect of acute ischemia-reperfusion on the expression of basic fibroblast growth factor and transforming growth factor ß in lung. Conference of Tissue Repair and Regeneration, May, 1999
51. Jiang Lixian, Fu Xiaobing, Sun Tongzhu, Wang Yaping，Yang Yinhui. The character of apoptosis in ulcer and scar. Conference of Tissue Repair and Regeneration, May, 1999
52. Jiang Lixian, Fu Xiaobing, Sun Tongzhu, Wang Yaping，Yang Yinhui. The apoptosis in injury skeletal muscle caused by ischemia-reperfusion. Conference of Tissue Repair and Regeneration, May, 1999
53. Sun Tongzhu, Fu Xiaobing, Jiang Lixian, Yang Yinhui, Wang Yaping. Apoptosis test in injury and ulcer tissue. Conference of Tissue Repair and Regeneration, May, 1999
54. Fu Xiaobing, Sun Tongzhu, Wang Yaping, Yang Yinhui, Jiang Lixian, Zhou Baotong，Sheng Zhiyong Comparative study of EGF and bFGF on tissue healing after injury. Conference of Tissue Repair and Regeneration, May, 1999
55. Fu Xiaobing, Yang Yinhui, Sun Tongzhu, Wang Yaping, Jiang Lixian, Sheng Zhiyong. The impact of intestine ischemia- reperfusion injury on endogenous bFGF and TGFß expression in kidney. Conference of Tissue Repair and Regeneration, May, 1999
56. Fu Xiaobing, Yang Yinhui, Wang Yaping, Sun Tongzhu, Jiang Lixian, Sheng Zhiyong. Ischemia-reperfusion reduced bFGF expression in skeletal muscle. Conference of Tissue Repair and Regeneration, May, 1999
57. Fu Xiaobing, Jiang Lixian, Sun Tongzhu, Yang Yinhui, Li Quanyue， Sheng Zhiyong. The characteristics of apoptosis in three chronic ulcers. Conference of Tissue Repair and Regeneration, May, 1999
58. Fu Xiaobing, Jiang Lixian, Yang Yinhui, Sun Tongzhu, Wang Yaping, Zhou Baotong，Sheng Zhiyong Ischemia-reperfusion cause apoptosis and growth factor expression changes in intestine. Conference of Tissue Repair and Regeneration, May, 1999